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PDO100 and PDO200
Next Generation Collagen Stimulating Liquid Threads

As we age, our skin loses its youthful collagen and elastin store thanks to sun damage, oxidative stress and wear and tear. There are many ways to counter this issue or to slow down the body clock. One of them is to use PDO100 and PDO200 to stimulate your body's natural collagen production. 


Unlike regular hyaluronic acid or HA skin boosters, PDO100 does more than a mere boost of intense hydration to revive lackluster and tired-looking complexions. At the heart of PDO100 lies the FDA-approved active ingredient Poly-P-Dioxanone or PDO, a completely biodegradable agent that has been used for over 3 decades for surgical sutures. In recent years, minimally invasive, non-surgical thread lift with PDO threads has become a much sought after aesthetics procedure for those in the know. This is because PDO can stimulate collagen renewal in the skin. However, as thread lifting may not a first line treatment of choice for everyone, PDO100 now offers an alternative to reap the dermal benefits of threads in a relatively simple, and fuss-free way.

What makes PDO100 unique is the smooth spherical micro-particles with added carboxy-methyl cellulose. This formulation allows PDO100 to rejuvenate skin when introduced via a series of microinjections. In short, an injectable, bioremodelling concoction of ‘liquid threads’ is born. Hence, it is affectionately known in our clinic as the liquid thread lifter.

PDO100 brings forth an exciting protocol in the field of non-invasive aesthetics procedures that allows individuals to enhance skin quality in a safe, natural and effective manner. It is readily incorporated into the the skin, is well tolerated to stimulate and support your body’s own collagen production. PDO100 features smaller particle size and is best administered as a skin booster superficially.


Improve Skin Texture

Fine Lines


Reduce Pore Size

Hydrates and Plumps Up Aged Skin


The stronger PDO200 is the recommended option if we want to restore volume in facial areas that have lost their natural youthful fullness. These include deflated cheeks, temples and forehead and it is especially good for the under eye hollowing. The under eyes are traditionally a difficult area to treat and the usual hyaluronic acid fillers can cause unwanted fullness or eyebags as a result of over-correction. PDO 200 works to regenerate the body’s own collagen and eliminates the problems associated with traditional fillers. It can also be applied to the laugh lines, neck lines and aging skeletal hands.

Treatment Areas and Indications:

  • Under eye hollowing
  • Temple hollowing
  • Deflated cheeks
  • Forehead
  • Laugh lines (nasolabial and marionette lines)
  • Neck
  • Decolletege
  • Hands

A primary course of 3 treatments (either standalone PDO100 or PDO200 or even combined PDO100 and PDO200) done at monthly intervals is ideal to improve not just hydration, but also the tone and elasticity of treated skin.

P.S. Read more in our 'PDO Thread Lift Explained' blog post here!


How does the treatment procedure work?

With over 30 years of global use (in surgery to stitch wounds and tissue organs), PDO has been proven to be 100% biodegradable and safe for human use. By administering this product through microinjections in small, titrated volumes over the whole face or in targeted areas, PDO100 stimulates the production of collagen and elastin in a natural way. This in turn boosts hydration and firmness of the skin and also rejuvenates sagging areas and reduces signs of dermal aging.

How does the treatment feel like?

You may experience mild discomfort during the treatment. With the use of a
topical anaesthetic/numbing cream and the aid of the professional, medical grade Zimmer cooler, the procedure is generally very well tolerated by the majority. There can be pinprick marks with slightly raised bumps at the injection sites immediately post treatment.

What can I expect afterwards?

The composition of PDO100 permits micro-bolus injection in a superficial plane without the risks of lumps, contour irregularities or tissue bulking, and there is no requirement for post-injection massage.

There may be slight pain, swelling or redness which will subside in a few days. There may occasionally be slight bruising which can be covered up using make-up the next day. Most can return to normal social activities right away.

We advise to avoid strenuous physical activity, hot saunas/steam baths and alcohol consumption for 24 hours.

What kind of results can I expect?

PDO100 is a new class of bio-remodelling skin booster that not just hydrates, but improves general skin quality for healthier and more youthful looking complexions. By boosting your skin’s own innate source of collagen, PDO100 leads to smoother texture, bounce, plumpness and skin elasticity. When paired with PDO200, it remodels skin and gives rise to natural yet noticeable improvements in facial contour. All this is achieved with a fairly straightforward and safe treatment that does not disrupt one’s daily routine.

You may observe a reduction, or even complete disappearance of fine lines depending on your true skin age. Even for those with more severe skin wrinkling, the textural improvement would not go unnoticed.

How long will my results last?

Depending on the condition of your skin, your diet and lifestyle, age and genetics, the positive outcome of a primary course of 3 sessions of 1 vial of PDO100 skin booster treatment done a month apart will generally last for 9 to 12 months. Following this, a booster session can be performed every 3 to 6 months for regular maintenance or to achieve greater facial rejuvenation goals if so desired. As part of sound medical advice, a healthy lifestyle, effective sunscreen and skin care is always important to feel and look youthful.

Who is a good candidate?

PDO100 and PDO200 are novel ways of introducing a time-tested material as an anti-aging treatment. This is designed to restore your skin to its former glowing glory in a completely natural way. It is suitable for all ages, men and women of all skin types especially for those over the age of 30 who want to rejuvenate tired, dull and lacklustre skin. This treatment increases firmness and skin elasticity to give fine lines, wrinkles and sagginess the chop without “running the risk of an over-filled pillow face”.

PDO200 in particular addresses periorbital or undereye signs of aging with finesse, treating underage hollowing and dark eye circles effectively without the risk of prolonged swelling, often a dreaded side effect of traditional hyaluronic acid or HA fillers when used in these areas.

Can it be used on other parts of my body?

PDO100 and PDO200 are most commonly used for the face but they can also be effectively applied to help revitalise the neck, décolletage, and hands. The neck especially is an oft-neglected body part that is becoming an increasing popular area to treat with a bio-remodelling substance due to its ability to help reduce crepe-like skin and sagginess for a firmer, and more youthful looking appearance.

Have any questions? We're just a call or text away. 
Freia Medical Logo
  • 435 Orchard Road #19-03, Wisma Atria Office Tower
    Singapore 238877
  • +65 6735 8180


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