October 6, 2020

Am I the right candidate for Rejuran?

Salmon is widely considered as one of the most nutritious foods on the planet and is credited with everything from extending a person’s lifespan to preventing heart attacks and cancer. Not only does salmon possess one of the highest omega-3 contents, it is also packed with tons of other vitamins and minerals as well.

For beauty and health lovers, the potential of this fish takes shape as mains, pills, drinks and topical creams. A published scientific paper in the International journal of cosmetic science as early as 2010 noted that when 3% DNA-Na cream harvested from salmon milt was rubbed onto the male subjects for 12 weeks, there was significant improvement in skin elasticity more than the control cream after the fourth week. One could not help but wonder what can be achieved to have this essence injected directly into the skin! Fast forward that to 2017 and from then till now, this is exactly what Rejuran promises to bring to the table.

What is Rejuran?

Rejuran is an injectable anti-aging skinbooster hailed from South Korea that is made up of polynucleotide chains or DNA fragments derived from the germ cells of salmon. Also known in the mandarin speaking market as 婴儿针 or “baby skin injectable”, Rejuran in a nutshell teaches aging skin cells to behave in a youthful manner by repairing damaged dermal cells and facilitating collagen growth. Starting off with Rejuran Healer for facial and neck rejuvenation, it has since added Rejuran I and Rejuran S to its repertoire to specifically target periorbital signs of aging and acne scarring.

Why are polynucleotides desirable for good skin?

Nucleotides are the basic building blocks of our DNA and therefore keeps the integrity of our skin structure. I like to describe them as the basic Lego blocks presented to our skin cells, and they will work in overdrive to repair whatever skin woes we faced. Polynucleotides are essentially molecules consisting of multiple nucleotides. As aging progresses, even the most powerful antioxidants and the best sunscreen will not be enough to fully heal the skin due to insufficient stores of naturally occurring DNA stores. Acne marks stay for longer than welcomed, pigmentation not seen in your 20s surfaces, fine lines start to creep all over the place and wrinkles deepened to become permanently etched into the skin. Hence, it is vital to maintain the integrity of our skin’s DNA for overall skin health to delay or reverse the onslaught of these undesirable signs of skin aging.

Why do some people age better than others?

Our genetic makeup forms an integral part which influenced how quickly we aged. By observing how the looks of your mom and granny has changed over the years, it is as good as getting a sneak peep into the crystal ball at your future self. If your family tends to not show their years easily, then you have got that on your side. With each passing year, our regulation of DNA gradually gets disrupted with dwindling stores of nucleotides the basic Lego building blocks for skin repair and renewal, making it an important contribution to intrinsic aging. However, this does not hold true for everyone as there are people whose DNA appear youthful despite their advanced year. Bingo— these are the “Peter-Pans” who strike it big in the genetics lottery.

How can Rejuran help?

If hereditary speaking you have drawn the shorter straw, get round your shortfall and transform an aging complexion from drab to fab with Rejuran. Studies have shown that salmon DNA is remarkably similar to that found in humans. Through a rigorous purification process that removes any antigens or proteins that might cause allergic, immune reactions or bio-incompatibility issues, Rejuran packaged and re-imagined precious polynucleotides in an injectable form, derived from salmon germ cells also known as salmon milt, or in Ariel mermaid to human language google translate - salmon sperm. Via a series of microinjections, an exceedingly rich source of polynucleotides which are comparable to the Lego blocks of our very own DNA is introduced directly into the skin where they are most needed. By “tricking” our skin cells into believing that these added nucleotides are our innate source, Rejuran “activates” the healing properties of skin by providing the basic building blocks required for healthy DNA synthesis. The regenerative capability of aging skin cells is thus revived as Rejuran makes your skin behave like it is younger again.

What kind of skin benefits can I expect from Rejuran?

By providing a readily available store of raw material or basic building blocks for DNA synthesis to affect the various permutations of cellular repair and renewal, some of the most desired skin benefits of Rejuran include:

  • Brightening of dull and lacklustre complexions with improved radiance
  • Lightening of skin pigmentation for a more even skin tone
  • Textural improvements with general smoothening and pore size reduction
  • Improving the tone of loose and aging skin in need of hydration and firming
  • Diminishes the appearance of fine lines and wrinkles
  • Rejuran I greatly improve the elasticity of the peri-orbital skin and thus effectively reduces Crow’s feet, fine undereye lines and dark eye circles
  • Rejuran I also help to improve the appearance of a crepey neck and horizontal neck rings
  • Rejuran S either as a standalone treatment or combined with Rejuran Healer effectively addresses all types of acne marks and scarring

Is the treatment painful?

I am not going to lie or pitter patter around this, Rejuran microinjections do cause a fair bit of discomfort and some patients might shed a tear or two. The good news is, from personal experience over the last 3 years, there is close to 100% patients’ return rate as the results garnered after each session motivates and speaks for itself. Numbing cream is applied prior to treatment for 10 to 15 minutes to minimize any pain or discomfort. Multiple microinjections are then administered to the identified problem area(s) under a constant stream of cold air emitted from the Zimmer air cooler to make the whole procedure even more tolerable.

Why is Rejuran uncomfortable?

The outcome of your Rejuran treatment is largely dependent on the skills and expertise of the injector. For Rejuran to exhibit its skin benefits, it must be placed exactly under the skin or intra-dermally. For those old enough to recall, this is like administering your BCG injection, whereby a small wheal or mosquito bite is created under the skin. The discomfort is not from the extremely fine needle tip poking the skin, but rather from the introduction of physical product into the correct plane of the skin. As the intra-dermal space consists of cells knitted closely to one another, there will be resistance and discomfort when the product pushes through. With acne scarring, skin tethering is an added challenge to overcome. If the microinjections are placed deeper in the dermis where the cells are more loosely packed, there will be less discomfort and downtime experienced but this is not the ideal plane of placement if you are planning to harvest the maximal benefits of Rejuran. Furthermore, as skin thickness varies quite a fair bit over different parts of the face and neck, to ensure that every drop of product gets to the right destination with every poke I made, I choose to administer these microinjections manually over an injector gun although it’s more labour intensive and time consuming.

What kind of downtime do I expect?

Post treatment, you will be left with multiple “insect-bite-like” swellings, ranging from 3 to 8mm in size over the treated area(s). Unlike say HA skinboosters whereby the lumps could be due to the presence of physical product that need to be massaged down, these bumps are normal skin reaction and generally disappears within 1 to 3 days. If this really bothers you, an add-on LED Healite treatment which aids in skin healing will significantly shorten the downtime. In addition, the concurrent home use of Calecim professional serum containing 80% stem cell proteins is encouraged as part of our post treatment protocol to hasten recovery.

How often do I need to get the treatment done?

A primary course of 3 sessions of Rejuran treatments, done at 3-4 weekly intervals is recommended for optimal outcome. Some patients reported favourable changes to their complexion as early as 10 to 14 days post-treatment but bear in mind that Rejuran works by repairing and healing skin damage so unlike fillers, results are not immediate. If you are looking for instant gratification such as an immediate “perk-me-up” required to meet the deadline of an upcoming event scheduled round the corner, a liquid facelift with the Restylane True Lift technique +/- skinboosters might be better treatment options. After the intensive course of Rejuran, you can discuss with your physician and personalise a schedule to repeat it every 4-6 months to maintain or further enhance your skin quality.

Can Rejuran be combined with other procedures?

Top Certified Profhilo Aesthetic Certified Clinic Singapore

Rejuran can be performed as a standalone procedure or combined with lasers and other injectables for an even better outcome. For those favouring a “less is more” approach to anti-aging tweakments whereby subtle changes bring about a substantial difference, a combination of alternating Rejuran and Profhilo treatments is definitely on the cards. Like Rejuran, Profhlio is an anti-aging injectable that puts the wheels in motion in a completely natural way. Touted as a bio-remodelling “injectable skincare”, Profhilo engages 100% pure, unadulterated hyaluronic acid to address skin laxity and signs of aging through the bio-stimulation of collagen, elastin and adipocytes (fats) stem cells that were lost with the passage of time. While the strength of Rejuran lies in pore size reduction, uneven skin tone, pigment and scar correction, Profhilo’s merits lead towards intense dermal hydration, tackling fine lines, skin tightening and lifting. Without running the risk of an overfilled “pillow face”, a combination of both Rejuran and Profhilo will be the youth reviving experience of choice to turn back the aging clock with synergistic effects that translate to overall improvement greater than the sum of its parts.